Can I Use a PCIe NVMe SSD in a PCIe Motherboard Slot?

SATA Vs NVME Slot & Difference slot m2 nvme 2 DDR5 RAM slot Inside of MSI Cyborg 15 gaming laptop 12th gen i7 processor with Nvidia RTX 4060 8GB Graphics, having inch 144Hz screen · 1 NVMe SSD Gen4 slot instellen koffer Eight NVMe SSD slots on a PCIe x16 card Silent operation Add your own ultra-fast SSDs for Mac, Windows, and Linux

slot skywind ASUS support says NVMe is not supported I have seen other comments for this laptop that some people have used sata drives, but that seems like a step backwards